Download Update. Star Update. Star. Download the. free trial version below to get started. Double click the downloaded file. Update. Star is compatible with Windows platforms. Update. Star has been tested to meet all of the technical requirements to be compatible with. Windows 1. 0, 8. 1, Windows 8, Windows 7, Windows Vista, Windows Server 2. Windows. XP, 3. 2 bit and 6. Simply double click the downloaded file to install it. Update. Star Free and Update. Star Premium come with the same installer. Update. Star includes support for many languages such as English, German, French, Italian, Hungarian, Russian and many more. You can choose your language settings from within the program. Note to reader This page is a continuation of my exploration, Inside the Dell PCRestore Partition. If you arrived at this page directly from an outside link, you. Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get. Whether you are upgrading memory, or need a replacement, find the right memory for your Dell desktop or notebook by selecting the product line and the model. Download the free trial version below to get started. Doubleclick the downloaded file to install the software.
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There are different ways to download and install Code Blocks on your computer This is the easy way for installing Code Blocks.Download the setup file, run it on your computer and Code Blocks will be installed, ready for you to work with it.Cant get any easier than that Download a nightly build There are also more recent so called nightly builds available in the forums or for Debian and Fedora users in Jens Debian repository and Jens Fedora repository.Other distributions usually follow provided by the community Big Thank you for that Please note that we consider nightly builds to be stable, usually, unless stated otherwise.If you feel comfortable building applications from source, then this is the recommend way to download Code Blocks.Downloading the source code and building it yourself puts you in great control and also makes it easier for you to update to newer versions or, even better, create patches for bugs you may find and contributing them back to the community so everyone benefits.This option is the most flexible of all but requires a little bit more work to setup.It gives you that much more flexibility though because you get access to any bug fixing we do at the time we do it.No need to wait for the next stable release to benefit from bug fixes Besides Code Blocks itself, you can compile extra plugins from contributors to extend its functionality.Thank you for your interest in downloading Code BlocksIm fine working on Linux using gcc as my C compiler but would like a Windows solution.Any ideas Ive looked at DevC from Bloodshed but looking for more options. Amd Gpu Temperature Monitor Software . Declare View Resolver when view viewname is called from the Controller, the file jspviewname. Active Directory System AdministratorActive Directory Group Policy Management.Campus Active Directory, DoIT Help Desk.YouTube DoITs newsfeed Feedback Help Desk, 6082644357, helpdoit.Manage networks and help desks for free with Spiceworks.Active Directory management.Help Desk ticketing system.If you click Help Desk.CDesk. A complete free.You can call it as Helpdesk, complaint management, query management, ticketing system.Active directory.Helpdesk Ticketing System by Jitbit.Affordable, fast, lightweight and good looking Helpdesk Ticketing System with UNLIMITED users.Pu8eankWU/maxresdefault.jpg' alt='Active Directory System Discovery Log' title='Active Directory System Discovery Log' />All tickets at a glance.The main screen of the help desk software features a powerful grid showing all the information about your current tickets.You can easily sort and filter requests, review current statistics and even perform bulk operations without leaving the page.For example, assign multiple tickets to agents, merge, close, delete tickets etc.Different list modes let you switch between all, in progress and unanswered ticketing queues.In addition, you can switch to the assigned to you tickets, to tickets from a specific company, a specific customer etc.Whether youre a techsupport agent, an administrator or a manager, the grid easily adjusts to your current needs.This is the screen youre gonna be looking at for the most part of your workday, so weve literally spent years polishing it.Everything you see on this page updates in real time.You dont ever need to refresh the page all data you see is always current.Everything is neatly organized.Everything related to a ticket is shown on a single page the entire conversation, attachments, internal communications and other activity etc.You no longer need to dig through your support mailbox trying to find that email you got from a customer a week ago.All the features you need.When you need them.We know how hard it can be to stay on top of your game when dealing with hundreds of tickets every day.Our helpdesk ticketing system is not yet another thing on top of everything else you have to deal with.It is designed to be invisible and make your life easier without adding more complications.We have all the features you might need from an IT ticketing system two way email integration, file attachments, powerful ticket search, knowledge base and much much more.But the best part is, if you dont need a feature, you probably wont even see it and it wont stand in your way.Categories Tags. There is a lot more than writing replies to customers during a typical helpdesk agent workday.We need to move tickets around, merge and link them together, search for tickets etc.We probably spend half of our day doing all those things.Support tickets are being assigned to categories this is the main feature to help you organize things up a little.You can distribute tickets across categories manually, make customers choose a category during the ticket creation or do this automatically via Automation Rules see below or email engine settings.Categories provide many additional benefits you can assign team members to specific categories, build reports using only the tickets you need, easily search for tickets and much more.You can also add tags to your tickets.You can use tags in addition to categories, a ticket can even have multiple tags assigned to it.For example we add the feature request tag to easily find all the ongoing feature requests.Helpdesk Reports.Our Reports make it easy to keep an eye on your IT team performance.Jitbit has a set of built in reports that will give you insights about various things and a custom report tool that lets you build your own reports quickly.Automation Rules.Wouldnt it be nice to minimize the routine in our jobs Very popular with our power users, Automation Rules is a super powerful feature that lets you automate the most boring parts of your job.Basically its a built in if this do that modulei.OS Android. Jitbit Helpdesk comes bundled with free i.OS and Android mobile ticketing apps.They are incredibly fast even on the slowest connections, have the needed set of features and, as the app itself, very well designed.Knowledge base web portal for end users.Searchable FAQKnowledge base and the self service web portal for submitting and tracking tickets via the web interface.Allow end users to communicate with helpdesk technicians within the portal.Customize the web portal by adding your logo, favicon or even custom CSS.Track visits with Google Analytics or any other Java.Script tracking, assign permissions to Knowledge base articles.Help users solve trivial issues on their own.Both me and my co founder have tech support background.And Im so proud of the work weve done on our latest version.Amazing new UI, improved reporting, performance, outstanding email integration etc.I use this software every day as our own support ticketing system.Alex, founder and CEOWeb based help desk software.So, youve ended up on a yet another web based help desk page.We will save you some time and point out the key reasons why Jitbit is different Unlimited we are not priced per agent or per user.Same price for any number of agents.Full blown the app has everything you expect from a web based help desk software app 2 way email integration, nice user interface, file attachments, asset management etc.Youll find the detailed features list below.Hosted or self hosted we offer both hosted and on premise versions of our helpdesk ticketing system.This page describes the downloadable version i.Hosted Helpdesk Software service Saa.S. Try it now. Try our help desk Why JitbitExtremely affordable and all contracts include free upgrades within one year and discounted upgrades afterwards.Email integration instantly turns emails into help desk tickets, and sends out automatic email notifications to both users and support engineers.Integrates into your website generates a support widget for your web pages.Just copy paste two lines of Java.Script to your webpage and thats it you now have a support form on it. Amd Media Codec Package Radeon R5 . FREE evaluation version has no expiration download and test as long as you needUnlimited similar web based software is priced 1.Jitbit is unlimited.Extremely Easy for both end users and techsupport agents.Takes seconds to setup run the installer and start working in seconds.Reliable most advanced technical platform Microsoft ASP.NET and MS SQL Server.Key Features. Web based accessible from anywhere with just a browser, works on smartphones and touch devices.File attachments post documents, screenshots and PDFs.Asset management track your assets, assign it to your users.Knowledge base and Reports with an option to export to Excel.Secure different user roles and security permissions technicians can be assigned to different areas, no customer sees someone elses data, etcFlexible possible Windows integrated authentication integrate the IT ticketing system with your existing Active Directory users catalog.Multilingual Help Desk has been translated to 1.English, Arabic, Czech, Danish, Dutch, French, German, Hebrew, Hindi, Italian, Norwegian, Portuguese, Russian, Slovakian, Spanish, Swedish, Turkish.Source codes C source codes available for developers.How are the tickets being handled A customer submits a ticket using the web interface or by sending an email to a support mailbox.Support agents, responsible for the ticket category for example, email engineer for email related issues, or webmaster for website related tickets etc are notified of the new issue, and take it or assigned by the administrator.Jitbit Helpdesk includes an integrated discussion forum for every ticket, where customers and technicians post updates and interact with each other.The updates can be posted via email or the web app.After an issue is closed, it can be published to a knowledge base.Support ticket system tracks and handles your customers tickets and saves your technicians time.View inline help. 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The weather is getting warm, our energy is skyrocketing, and were ready to get our homes clean and organized Take advantage of this newfound energy and make HUGE STRIDES when it comes to the HOME ORGANIZATIONAL LIFE CYCLE. Get your weekly DIY fix with our customized newsletter. Thanks Youve been added to our list. Good stuff is on its way Deck Packages Learn how to build a deck with our deck packages. If youre building new or replacing an existing deck, youll find everything you need at RONA. This Ultimate Spring Cleaning Checklist can be used as a guide to customize your very own personal cleaning checklist. Make sure to snag the decluttering toolkit to help you get rid of that extra clutter sitting around the house too. Then, once your home is in order, Id love for you to follow along with us at Spring Cleaning 3. Its the best way to keep a Spring Clean home all yearOverall Spring Cleaning Choresdust crown molding and baseboardsdust ceiling cornersdust baseboards and clean scuff marksdustwash light fixtures and lampsdust ceiling fanswash doors look for scuff markswash wallstouch up paintvacuum or wash window curtainswash window blindsclean windowsdust bookcasespolish wood furniturewipe down and vacuum furniture clean the base and under cushionscondition leather furnitureremove stains from upholstered furniturevacuum and wash lampshadesdeep clean hardwood, tile, linoleum, and carpet flooringshampoo carpet DIY or schedule a professionalremove rugs to shake out, then vacuum, then clean under themvacuum all flooring, including corners and edgesclean air ventsdust around mirrors, picture frames, and wall hangingsreplace light bulbschange airfurnace filterreplace batteries in smoke detectorreplace batteries in carbon monoxide detectorschedule chimney sweepschedule termite or pest control maintenance. Spring Clean the Dining Roomeliminate unnecessary itemsdust crown molding, wall corners, and floor moldingscrub wallsclean and disinfect light switches and outletsdust and polish wood cabinetsdust and clean windows, inside and outclean and declutter hutch cabinets and drawerswash table linenswash table cushionsclean light fixtures and wash globesdisinfect table and wipe down all chairs, including legs and underneathremove rug, shake, vacuum and clean floor before replacing rug. Spring Clean the Bathrooms. Print this free bathroom cleaning checklist to clean easily and efficiently. Clean air vents. Clean and disinfect light switches and fixtures. Clean and disinfect toothbrush holders. Clean and refill soap dish andor pump. Clean light fixtures and wash globes Clean make up brushes. Percentage of Carpet in the Home is Shrinking. Back in 1976 when I opened Carpet Classics the amount of carpet in a home was approximately 80 of the available floor. Clean mirror. Clean shower caddy. Clean shower curtain and liner. Clean shower door frame. Clean shower glass heres a great way to prevent soap scum from building up on shower glass doors in the future. Clean plastic strip at the bottom of a glass shower door. Disinfect countertops. Dust and clean windows, inside and out. Polish faucets. Mop and hand scrub floors pay attention to special grout lines, corners, and moldingsScrub and disinfect toilet, including around base, under seat and around hinges. Scrub the bathtub andor shower. Scrub walls. Unclog and refill lotion dispensers. Wash bathroom cup. Wash floor mat. Wash handguess towels. Wash trash can inside and outWipe down cabinets, knobs, towel racks and toilet paper holder. Remove rust from toilet seat screws. Tighten toilet seat hinges. Clean bathroom exhaust fan. Clean shower head. Polish wood cabinets. Caulk around bathtub. Re seal tile and grout. Unclog drains the use this tip to prevent clogged drains in the futureToss beauty products not used over the past year. Toss expired make up. Clean, organize and de clutter cabinets and drawers. Clean, organize and de clutter bathroom closet. Spring Clean LaundryUtility Roomclean dryer ventclean inside washing machineempty washing machine drain pumpdust crown molding, wall corners, and floor moldingdust behind and underneath washer and dryersweep and mop floorsreseal tile groutwash wallsclean and organize contents on shelvingeliminate unnecessary cleaning productsinstall organizers to hold cleaning productsdisinfect door knobs and light switch plates. Spring Clean Living RoomFamily Areastake anything that doesnt belong in the room and put it in the correct locationdust crown molding, wall corners, and floor moldingvacuum and shampoo carpetvacuum under furniture and in between cushionscondition leather furnituredust ceiling fansswitch ceiling fans to spin clockwiseclean lights and wash light globesdust lampsvacuum lamp shadesdeclutterdust and polish furniture and bookshelvesdust edges of wall hangings, mirrors, and picturesclean windows and window sillsremove scuff marks from doors and moldingsdisinfect door knobs and light switch platesdust electronicsorganize electronics and accessoriesdisinfect remote controls and gaming devices. Spring Clean Bedrooms. Spring Clean Kid Stuff. Spring Clean OfficeCommand Centerspring clean your paperworkclean out files and shred unneeded documentsupdate home inventory documentsreview insurance policiescheck credit reportspring clean your computer, keyboard, and mouseclean and organize desk drawersdust and polish wood furnituredust bookshelves. Spring Clean Miscellaneous Items. Spring Clean Outsidesweep deckpower wash deckstain deckpower spray sidingtouch up paint trim, wood, doors, and shutterspower wash garage doorclean outside door frameswipe away cobwebsshake out entry matclean grillclean and repair guttersreplace broken bricks, wood, or stoneclean outdoor light fixtureswash outside windowsclean outside patio furnituretrim trees, bushes and shrubberycheck and repair sprinklersinspect roof shingleswipe away cobwebsplant flowersplant gardenadd mulchclean outdoor trash cansclean out garagewash and wax vehicles. Id love to hear from you What would you add to the listP. S. When youre finished Spring Cleaning, consistently clean these the areas in your home, one day at a time. Spring Cleaning 3. EASIEST way to make that happen. That way youll never have to work this hard cleaning your home againHow to Vacuum Carpet i dream of clean organized simple productive One of my chores growing up was to vacuum the carpet. My idea of vacuuming was to put a few lines in the carpet as evidence and move on about my day. Honestly, I wasnt trying to shortcut the system. I just didnt know any better. Until one day when my teenage step brother showed me how to vacuum carpet correctly. Surprisingly, his instructions have stuck with me all these years. As I was vacuuming my own house the other day, it occurred to me that carpet across the world could be dirty not for lack of trying, but because it isnt being vacuumed properly Because I want you all to have sparkling clean homes, I thought vacuuming might be a nice little topic to cover in our Cleaning Tips section. There are a ton of topics related to vacuuming, but for today well start with how to vacuum carpet correctly. Since I dont necessarily trust teenage boys 1. I googled how to vacuum. You know what I found The consensus is he was right So, here are the steps I was taught when it comes to vacuuming. Maybe you can use them to teach your kids how to vacuum too Step 1 Use the vacuum cleaner crevice tool to clean around the edges of your room. Have you ever noticed a dark line around the edge of your carpet If you skip this step, dust and dirt accumulate over the years making it nearly impossible to clean the edges of your carpet. This step does take an extra few minutes, but its worth it to keep your carpet in good shape Step 2 Use the vacuum crevice tool or flat universal piece to clean under furniture. I cant tell you how many dust bunnies Ive found when vacuuming under furnitureand I vacuum all. I also find toy cars and legos so I do my best to visually check for items that can be sucked up by the vacuum Step 3 Starting at the corner farthest from the door, vacuum left to right and then front to back. It may seem like duplicate work but there is dirt stuck in the carpet fibers that will most likely be missed if you dont vacuum both directions. Step 4 Vacuum your way out the door. This step isnt 1. Of course, if your house is anything like mine, there will be tiny foot imprints in the carpet before you even have time to finish the rest of the house. But, thats okay. Its worth it And if you have vacuuming on your cleaning schedule, youll get those vacuum lines again very soon So, Id love to hear from you How do you vacuum carpet Who taught you the right way to vacuum And who have you taught Microsoft claims Bing, its search engine for people who have just unboxed a new computer and are trying to find out where to download Chrome, is bigger than you think. Good Hackers Can Do Bad Things, Too. Famed white hat hacker Marcus Hutchinsbetter known as Malware. Techwas arrested by the FBI yesterday while trying to fly home to the United Kingdom from Las Vegas. The 2. 2 year old security researcher gained mainstream fame earlier this year as the guy who stopped the destructive Wanna. Cry ransomware from spreading, and had been partying with friends near the Black Hat and Defcon hacker conferences before his arrest. Now, he faces serious federal charges for allegedly creating the Kronos banking trojan. But hes supposed to be the good guy Heres the thing Good people do bad things sometimes. Its possible that good hackers, the ones we celebrate for stopping malware, also create malware, perhaps for profit or perhaps because theyre bored. Its possible, but some people just cant believe that Hutchins would ever do something like this We dont know if Hutchins is guilty. Thats up to the courts to determine. However, what we know so far about the young mans precarious situation is intriguing to say the least. In the days leading up to his arrest, Hutchins was going big. During the hacker conferences, Hutchins was throwing parties at a 1,9. Airbnb which, incidentally, is home the largest private pool in Las Vegas, Gizmodo alum William Turton reports at the Outline. Hutchins also rented a Lamborghini and asked his Twitter followers where he could find a race track. He contemplated renting a helicopter for a tour of the Grand Canyon. He shot a very scary machine gun at a shooting range. Spending lots of money and having fun isnt against the law, but it is curious in retrospect. The recently unsealed federal indictment claims that Hutchins not only built the Kronos malware, which enables a hacker to steal bank credentials, but also advertised it on Alpha. Bay, the dark web marketplace that US and European authorities seized a couple weeks ago. Its unclear if Hutchins arrest is connected to that seizure. The indictment claims that Hutchins sold Kronos, at least once, for 2,0. The indictment also claims that Hutchins uploaded a video to You. Tube about how Kronos works, a detail that the Department of Justice thinks is incriminating evidence. Did federal authorities let Hutchins party his face off during Defcon and Black Hat, so that they could collect more incriminating evidence against the young security researcher Did Hutchins money come the sale of malware that makes it easy for evil hackers to rob unsuspecting computer users Did Hutchins lie when he said he was donating the 1. Wanna. Cry to charity, instead choosing to spend the money on exotic car rentals and a lavish party house We dont know the answer to any of these questions, and we probably wont for quite some time. But it certainly is possible that a white hat like Hutchins possibly, maybe did some bad things a few years ago. In the hacker world, its not uncommon for hackers to start off wearing black hats and end up changing their ways. Usually they get caught doing the bad stuff and then spend some time in prison. Here are some examples. Kevin Paulson is the legendary hacker who became famous for taking over all of the phone lines that led to Los Angeles area radio stations so that he could be the 1. Porsche back in 1. He was arrested in 1. Now, hes a senior editor at Wired. Then, youve got Kevin Mitnick, another famous hacker. Mitnick was charged for over two dozen cyber crimes in 1. Now, he runs his own security company, consulting large companies and even the FBI on how to keep their data safe. And who could forget Samy Kamkar. When he was just 1. Kamkar created a worm that he unleashed on My. Space, where it soon became the fastest spreading computer virus in history. He pleaded guilty to a felony, avoided jail time, and was on probation for three years, during which he was not allowed to touch a computer. Now, hes one of the most famous white hat hackers in the world, spotting vulnerabilities in everyday devices and advocating for better privacy. Hes even testified before Congress. One thing deserves repeating, though We dont know if Hutchins is guilty. Its entirely possible that the feds got the wrong guy, and we can all go back to remembering Malware. Tech for being the nice person who saved a lot of people from getting hacked and held hostage by the Wanna. Cry ransomware. If he did do it, however, he wouldnt be the first white hat hacker with a black hat past. In fact, hed be in good company. RIP, Microsoft Paint. MS Paint, the first app you used for editing images, will probably be killed off in future updates of Windows 1. Paint 3. D. Microsoft lists the 3. Windows 1. 0s next autumn update, a little X marking the end of an era. The app is certainly a relic, from a time when the casual computer user couldnt crack open Photoshop or Skitch or Pixelmator or thousands of web apps. MS Paint cant save image components as layers or vectors its for making flat static images only. It doesnt smooth lines or guess at your best intentions. It does what you tell it and nothing more, faithfully representing the herky jerky motion of drawing freehand with a computer mouse. Its from a time before touch, a time before trackpads. As more sophisticated options appeared, Paints janky aesthetic became a conscious choice. Paint became the metonym for that aesthetic, even if an image was actually created in another app. TV Tropes lists major limitations that came to define a certain look the wobbly freehand lines, awkward color handling, and inappropriate export settings that give Paint its distinctive look. In 2. 01. 4, Gawkers Sam Biddle noted Paints influence on conspiracy theory images, calling the form Chart Brut. In amateur detectives attempts at identifying the Boston Marathon bombers, the simplicity and jaggedness of Paint evokes the crazy wall aesthetic of red string and scribbled notes, apparently without irony. The same year, internet historian Patrick Davison explored Paints influence on the last decade of meme culture, particularly Rage Comics. The outsider art aesthetic feels appropriate to the relatable everyday content, and makes the art form unthreatening. Of course, Paint offered a few features to smooth things out, like the circle and line tools and the fill tool, all used in the stoner comics of the early 1. Crucially, those circles still had jagged curves. The bright colors of stoner comics are flat, as MS Paint didnt support gradients without an elaborate hack. Contrast those pixellated lines with the slick, stylish face from this art tutorial This slickness is built into Paints successor, Paint 3. D. From the moment you start sketching, Paint 3. D smooths out your art. It also supports automatic selection tools and content aware fill to rival Photoshops. By automatically improving art, Paint 3. D hides the process behind the image. Paints sloppiness is probably why rage comics got so popular. Looking at a rage comic, you can tell exactly how it was drawn, and how you might draw one yourself. By delivering exactly what the artist draws, MS Paint forms an image that the viewer can mentally reverse engineer and imitate. Unless you go absolutely nuts with it. Reddit user Toweringhorizon painstakingly assembled the drawing To a Little Radio using MS Paint tools like the oil brush, stretching the medium while maintaining a pixelated look. Its one of the top submissions to MS Paint subreddit, a beautiful collaborative art gallery. Scrolling through this art feels like flipping through the sketchbook of the most artistic kid in high school. Theres an accepted roughness, a desired minimalism. For example, the exquisite raindrops in the work above are reflected in a flat, featureless tabletop. Like a transistor radio, Paint might be showing its age, but this tenacious little gadget should not be underestimated. To a Little Radio doesnt even come close to testing Paints limits. As we say goodbye to the app that shaped an era, let us watch this bizarrely soundtracked time lapse of drawing Santa Claus in MS Paint on Windows 7 over the course of 5. We can only believe this is real because faking it would be even harder. Internal Medicine British Journal of Medical Practitioners. Authors. Article Citation and PDF Link. Abstract. Bacterial infections are associated with many autoimmune diseases involving chronic inflammation and demyelination. The possible mechanisms of bacterial involvement as aetiological agents or in the exacerbation of these diseases have been investigated intensively. NetCE is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. NetCE is accredited as a. This review focuses the role of bacterial infections in the pathogenesis of autoimmune, inflammatory and demyelinating diseases. Possible modes of pathogenic action of bacteria are discussed, viz. Toll like receptor signalling, the interaction of heat shock proteins with the immune system, and the role of nitric oxide. An auto regulatory loop might exist in the interaction of bacteria with the host and in pathogenic signal processing. These studies reveal potential therapeutic targets. Abbreviations AQP4 Aquaporin 4 AS ankylosing spondylitis CSF cerebrospinal fluid EAE autoimmune encephalomyelitis GB Guillain Barre syndrome HLA human leukocyte antigens HSP heat shock protein IL interleukin LPS lipopolysaccharides MAM Mycoplasma arthritidis antigen MHC proteins encoded by major histocompatibility gene complex MS multiple sclerosis NK natural killer cells NMO neuromyelitis optica NO nitric oxide NOS nitirc oxide synthase PCR polymerase chain reaction RA rheumatoid arthritis SLE systemic lupus erythematosus TLR Toll like receptors TNF tumour necrosis factor. Introduction. Bacterial and viral infections are commonplace in a variety of autoimmune and chronic illnesses such as the chronic fatigue syndrome myalgic encephalomyelitis, fibromyalgia syndrome, Gulf War illnesses and rheumatoid conditions. Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get. Review of State Medication PoliciesGuidelines Regarding Psychotropic Medications in Public Schools. Much attention is focused at present on the role of bacteria and the possible mechanisms of their involvement in the pathogenesis of several diseases. The route of infection and penetration and the immune responses of the host can not only make any bacterial infection pathogenic but probably can also determine the aggressiveness of the disease and the chance for full recovery. Therefore the two basic elements addressed here are the association between bacterial infection and autoimmune disease and the involvement of the immune system in the disease process. Bacterial infections in rheumatoid conditions. A wide variety of bacterial infections have been associated with rheumatoid conditions. Rheumatic diseases might have a manifold aetiology with varying genetic susceptibility, but bacteria related autoimmunity might be an important factor. Mycoplasma infection, e. M. pneumoniae, M. M. fermentans, has been strongly associated with RA rheumatoid arthritis5 8. There is often systemic infection of more than one species. Mycoplasma antigens induce both cell mediated and humoral immune responses. Enhanced levels of antibodies against MAM Mycoplasma arthritidis antigen have been found in sera from RA patients in comparison with antibodies against Staphylococcal enterotoxins A and B. Also antibody titers were higher in RA serum than in systemic lupus erythematosus, ankylosing spondylitis, psoriatic arthritis, Reiters syndrome, or healthy controls. The mycoplasma antigen MAM can activate T cells. MAM contains two domains, one of which can inhibit lymphocyte proliferation the second domain, which contains concanavalin A motif, is required for T cell activation. It can also up regulate natural killer cell activity. Furthermore, synovial tissues of RA patients contain T cells, which bear the same T cell receptors as used by MAM. The mitogen seems to be capable of initiating and exacerbating arthritic changes. MAM is a zinc dependent antigen that binds to MHC class II molecules. Zinc induces MHC protein dimerisation required for MAM binding, MHC induced cell cell adhesion, and efficient T cell activation. As discussed in later sections, MAM can alter cytokine expression profiles and activate and modulate nitric oxide synthase NOS signalling pathways. Bacterial DNA isolated from rheumatoid arthritis RA and juvenile arthritis has included Haemophilus influenzae, Bordatella and Yersinia as possible infecting organisms. Lyme arthritis, which resembles rheumatoid synovial infiltration by Borrelia burgdorferi, has often been suggested to be an autoimmune condition. The B. burgdorferi surface protein A Osp. A1. 61 1. 75 is recognised by T cells and HLA human leukocyte antigen DR molecules that bind this T cell epitope and to these events is attributed the development of autoimmunity following B. However, these decline with antibiotic therapy. Therefore, in spite of the perceived association, Drouin et al. Osp. A 1. 65 1. The epitope Osp. A 1. Lyme disease. Serum reactivity against Osp. A is also found in RA patients. Our knowledge concerning the interaction of B. Ghosh et al. 1. 9 have suggested cytokeratin 1. Gavanescu et al. 2. It is not known if this cellular organelle is involved with autoimmunity in RA. B. burgdorferi seems to be able to induce inflammatory responses including secretion of cytokines and cellular responses of the T helper cell 1 Th 1 type. Beermann et al. 2. LV from this bacterium and incorporated them into peripheral blood mononuclear cells. The resultant LV T cells were predominantly the immune effector CD8. Furthermore, these cells destroyed autologous T cells carrying LV. These data do indeed support the existence of an autoimmune condition. Overall, a conservative conclusion would be that the molecular mimicry and autoimmunity thesis is yet to be fully tested. Proteus mirabilis has been implicated in the pathogenesis of RA2. OA2. 7, 2. 8. Again, the HLA DRB1 alleles appear to be the major genetic susceptibility factors as postulated some years ago. Bacterial infection associated with other autoimmune conditions Bacterial infections have been identified in association with other autoimmune conditions besides RA. Members of the Enterobacteriaceae family are associated with autoimmune conditions such as Kawasaki syndrome and Graves disease. Demyelinating diseases have been a focus of active investigation in the past few years. Kollef et al. 3. 0 suggested that central and peripheral nerve demyelination might occur following M. Since then patients with the autoimmune condition SLE systemic lupus erythematosus have been investigated for mycoplasma infections. Early studies revealed differences between SLE patients and control subjects in respect of genitourinary mycoplasma infections. However, the deployment of more sensitive methods of detection has not supported these early claims. Runge et al. 3. 2, for instance, found no difference in the incidence of Ureaplasma urealyticum in SLE patients, and they discount the notion that this mycoplasma species has any role to play in the pathogenesis of SLE. Nonetheless, there should be no serious doubts that mycoplasma infection can lead to demyelination. The demyelinating neuropathy known as Guillain Barre GB syndrome often has pathogenic association with bacterial infections. Campylobacter jejuni, Haemophilus influenzae and M pneumoniae have been implicated as possible causative agents of GB. C. jejuni is the major infecting organism here together with M. GB is associated with the presence of antibodies against galactocerebroside, which is a major component of myelin. Some bacterial LPS lipopolysaccharides apparently bear molecular similarity to the human gangliosides GM1, GM1b, GD1a, and Gal. NAc GD1a of the motor axolemma and are said to be the target epitopes for antibodies occurring in the GB subtype acute motor axonal neuropathy. The antiganglioside antibodies cause axonal neuropathy. The host immune response to LPS moieties of the HB9. C. jejuni cross reacts with human nerve gangliosides and induce GBS3. Multiple sclerosis MS is a chronic inflammatory and demyelinating disease of the central nervous system. The pathogenesis of MS is possibly a consequence of autoimmune condition or infection by viral or bacterial agents. Both infections lead to the development of demyelinating plaques. Bacterial infections can evoke immune responses and induce demyelination. Infections of the brain parenchyma are sequestered from the immune system. 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Prudential Singapores agency unit Peter Tan Organisation to join rival insurer Aviva. The latest episode is likely the biggest one off act of poaching seen in the insurance sector here. The mass resignation has also caught the attention of the regulator and the man in the street who are concerned about the risk of mis selling by departing agents to meet sales targets at the new firm. The Sunday Times takes a closer look at the impact of poaching and what customers should know to protect their interests. Why poach rival agents. The practice of poaching agents has been around for several years as insurers race to drive growth by expanding their agency forces amid intense rivalry. It typically involves insurers and financial advisory firms trying to outbid one another in wooing top performers and their teams by offering better and more tempting sign on deals with upfront lump sum payments and bonuses. Those who practise this style of large scale recruiting believe it is a faster and more effective way to hire experienced agents without having to spend money and many hours training them. The company which acquired the rival agents via poaching instantly has a pool of experienced agents with high motivation to perform, thus increasing its revenue and shareholder value, said Mr Roland Yeo, president of the Insurance and Financial Practitioners Association of Singapore Ifpas. He pointed out that when a company buys over insurance agents or even entire agency units within an insurer, the valuation of such acquisitions should be based on the competency of the sales force alone, without the client base this sales force would have built up over the years. This is because the client base remains the asset of the original company, not the agents, because the rights to the personal data belong to the company, not agents, he said. The crossover agents would have to build the business from scratch again, but faced with the pressure of meeting the targets tied to the attractive packages, problems like infringing the Personal Data Protection Act PDPA by accessing their previous clients data, mis selling or churning could arise, added Mr Yeo. Installing Cctv At Home Singapore Mp3Datamine is cheap and low cost CCTV surveillance system for home CCTV system, office CCTV system, warehouse CCTV system, factory CCTV system, industrial CCTV system. Virginias Board of Elections voted unanimously to decertify all of the states touchscreen voting machines, which are considered by cybersecurity experts to be. Churning happens when customers surrender their policies to their detriment and the proceeds are used to buy new plans from the agents new employer. Impact of poaching rival agents POTENTIAL MIS SELLING OF POLICIES. Financial experts worry that poaching may result in potential mis selling and churningswitching by agents under pressure from their new outfit to meet sales targets. In this particular case, AIAs offer to departing GE agents included sign on bonuses and a five year bond period during which the monetary incentives could be clawed back if sales quotas are not met. Insurers may also increase premiums or reduce cash values to recoup the costs related to such poaching activities and consumers will get the short end of the stick. Mr Christopher Tan, chief executive of Providend, said For exiting agents, because they have been paid a huge payout package which usually comes with conditions such as meeting sales targets, there is always a potential risk of getting existing clients to switch out of their old policies in exchange for new policies now sold by the exiting agents. Of course, whether this will actually happen depends on individual agents but such a risk is present. Ifpas Mr Yeo said Poached agents in the new company have to find new sales to keep their packages. Faced with the risk of losing their compensation, they could fall prey to the temptation to engage in mis selling and churning. Mr Tan Chuan How, chief executive of AIA Financial Advisers, said it has put measures in place to protect its customers, including ensuring that its representatives sell policies which meet the customers individual needs. Its agents are evaluated and subsequently paid based on criteria set in its balanced scorecard assessment, in which AIA looks at both their sales performance as well as the quality of financial advice and service rendered to customers. AIA also strongly advocates a full financial review of a customers financial position before recommending suitable financial products to meet the customers needs, AIAs Mr Tan added. In the aftermath of the resignation of the 3. GE agents, the Monetary Authority of Singapore issued a statement to say it recognises that large scale movements of representatives from one financial institution to another could give rise to risks of improper switching of insurance policies and cause disruption to business operations. The offering of high sign on bonuses and other financial incentives may also drive up costs in the industry, it warned. Representatives must ensure that their product recommendations are suitable, given their customers needs, risk profile and financial circumstances. In addition, financial incentives offered by an insurer to recruit existing representatives from another firm to join the insurer or its related financial advisory firm, cannot be charged to the insurance funds. If the insurer disburses financial incentives, the amount must be borne by the insurers shareholders, MAS added. HEALTH AND LIFE INSURANCE POLICIES. Industry observers say that the first policies that are likely to be churnedswitched are the term life, health and accident plans, as these do not have cash values. Be on the alert when you are asked to surrender your hospitalisation and healthcare plans, and buy new ones from another insurer. It is prudent to find out if you have any pre existing conditions, and check if such switching is to your detriment or your benefit. There have been policyholders who were persuaded to switch their policies only to find themselves out of cover as the next insurer declined their cover due to pre existing medical conditions. Generally, buying a life insurance policy is a long term commitment. Do note that if you surrender or terminate your policy before its maturity, you may incur penalties for early termination. This is because there are high costs involved in early surrender of policies. If you own a life insurance policy with cash values, ask for the updated guaranteed and non guaranteed surrender values so as to ensure you do not suffer any loss. ORPHAN POLICIES. When large numbers of agents leave en masse, a huge number of policies will be left orphaned without servicing agents in their wake. A large number of clients will be left in the lurch, and agents in the original company will face increased workload servicing these clients with or without compensation, said Mr Yeo. Providends Mr Tan said that theoretically, new agents will be assigned to take over and service the affected clients. However, the practical truth is that because the new agents do not have a relationship with these clients and also might not be compensated for these policies sold, these clients might be of a lower priority to them. Theoretically, if the new agents serve these orphan clients well, they might get new businesses from these clients. Practically, most of these clients will still maintain the relationship with exited agents and might continue to buy from the exited agents. As such, the new agents might not have the interest to invest in the relationship, he said. POTENTIAL BENEFITS FROM WIDER PRODUCT RANGE. On a positive note, Providends Mr Tan said that departing agents may move to a firm which offers a wider product range. If that happens, they would be able to provide a more comprehensive service to customers. KNOW WHAT FA FIRMS OFFER. Not all customers are savvy enough to distinguish which financial advisory FA firm offers a wider range of products and which firms can really claim to be independent, said Mr David Choo, managing director of Promise. Land Independent. Window Grill Singapore 1 Window Grill Gates Supplier in Singapore. Why We Are Leading Window Grill Supplier in. Singapore In your home proper windows placement highly. To get. all these outcomes from your home window without. 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